zhenghongxiang@fudan.edu.cn

摘要

从事生物信息学和人类群体遗传学相关工作，主要为基于线粒体基因组(Mitochondrial DNA, mtDNA)的人类进化遗传学研究，涉及三个层面：1）研究人群的迁徙、扩张和适应等进化历史。2）研究线粒体DNA突变与长寿、肥胖、高原适应等复杂性状之间的关联。3）通过线粒体DNA异质性研究个体内水平进化。其次，也涉及一些细菌和病毒的分子进化研究。

1. Zhang M†, Zheng HX†, Yan S#, Jin L#. Reconciling the father tongue and mother tongue hypotheses in Indo-European populations. National Science Review, 2019, 6(2):293-300.
2. He L†, Zheng HX†, Wang Y, Le KY, Liu Q, Shang J, Dai Y, Meng H, Wang X, Li T, Gao Q, Qin J, Lu H, Otto M#, Li M#. Detection and analysis of methicillin-resistant human-adapted sequence type 398 allows insight into community-associated methicillin-resistant Staphylococcus aureus evolution. Genome Medicine, 2018, 10(1):5.
3. Lin X†, Zheng HX†, Davie A, Zhou S#, Wen L#, Meng J, Zhang Y, Aladaer Q, Liu B, Liu WJ, Yao XK. Association of low race performance with mtDNA haplogroup L3b of Australian thoroughbred horses. Mitochondrial DNA Part A DNA Mapping, Sequencing, and Analysis, 2018, 29(2):323-330.
4. Zheng HX†, Li L†, Jiang XY†, Yan S, Qin Z, Wang X#, Jin L#. MtDNA genomes reveal a relaxation of selective constraints in low-BMI individuals in a Uyghur population. Human Genetics, 2017, 136(10):1353-1362.
5. Kang L†#, Zheng HX†, Zhang M, Yan S, Li L, Liu L, Liu K, Hu K, Chen F, Ma L, Qin Z, Wang Y, Wang X, Jin L#. MtDNA analysis reveals enriched pathogenic mutations in Tibetan highlanders. Scientific Reports, 2016, 6:31083.
6. Yin M†, Zheng HX†, Su J, Feng Z, McManus DP, Zhou XN, Jin L, Hu W#. Co-dispersal of the blood fluke Schistosoma japonicum and Homo sapiens in the Neolithic Age. Scientific Reports, 2015, 5:18058.
7. Li L†, Zheng HX†, Liu Z, Qin Z, Chen F, Qian D, Xu J, Jin L#, Wang X#. Mitochondrial genomes and exceptional longevity in a Chinese population: the Rugao longevity study. Age (Dordr), 2015, 37(1):9750.
8. Kang L†#, Zheng HX†, Chen F, Yan S, Liu K, Qin Z, Liu L, Zhao Z, Li L, Wang X, He Y, Jin L#. mtDNA lineage expansions in Sherpa population suggest adaptive evolution in Tibetan highlands. Molecular Biology and Evolution, 2013, 30(12):2579-87.
9. Zheng HX, Yan S, Qin ZD, Jin L#. MtDNA analysis of global populations support that major population expansions began before Neolithic Time. Scientific Reports, 2012, 2:745.
10. Zheng HX†, Yan S†, Qin ZD, Wang Y, Tan JZ, Li H, Jin L#. Major population expansion of East Asians began before Neolithic Time: Evidence of mtDNA genomes. PLoS One, 2011, 6(10):e25835.