zhengyuanting@fudan.edu.cn

摘要

研究方向: 从事药物基因组学与临床个性化用药的基础与转化研究。采用高通量组学、生物信息学和分子生物学等手段，研究肿瘤、2型糖尿病等疾病个性化用药标志物与治疗新靶点。

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1. Qing T, Zhu SB, Suo C, Zhang L, Zheng YT*, Shi LM*. Somatic mutations in ZFHX4 gene are associated with poor overall survival of Chinese esophageal squamous cell carcinoma patients. Scientific Reports. 2017; 7(1): 4951.

2. Zhu JH, Chen G, Zhu SB, Li SQ, Wen Z, Li B, Zheng YT*, Shi LM*. Identification of tissue-specific protein-coding and noncoding transcripts across 14 human tissues using RNA-seq. Scientific Reports. 2016; 6: 28400.

3. Wen Z, Chen G, Zhu SB, Zhu JH, Li B, Song YJ, Li SQ, Shi LM, Zheng YT*, Li ML*. Expression profiling and functional annotation of noncoding genes across 11 distinct organs in rat development. Scientific Reports. 2016; 6: 38575.

4. Zhou N#, Zheng YT#, Xing JF, Yang HY, Chen HM, Xiang XQ, Liu J, Tong SS, Zhu B, Cai WM. Application of a new dynamic model to predict the in vitro intrinsic clearance of tolbutamide using rat microsomes encapsulated in a Fab hydrogel. Drug Metabolism and Disposition. 2016; 44 (1): 40-9.

5. Zheng YT, Qing T, Song YJ, Zhu JH, Yu Y, Shi WW, Pusztai L, Shi LM. Standardization efforts enabling next-generation sequencing and microarray based biomarkers for precision medicine. Biomarkers in Medicine. 2015; 9(11): 1265-72.

6. Zheng YT, Yang HY, Li T, Zhao B, Shao TF, Xiang XQ, Cai WM. Amiloride sensitizes human pancreatic cancer cells to erlotinib in vitro through inhibition of the PI3K/AKT signaling pathway. Acta Pharmacologica Sinica. 2015; 36(5): 614-26.

7. Shao TF, Zheng YT*, Zhao B, Li T, Cheng KG, Cai WM. Recombinant expression of different mutant K-ras gene in pancreatic cancer Bxpc-3 cells and its effects on chemotherapy sensitivity. Science China Life Sciences. 2014; 57(10): 1011-7.

8. Yang HY#, Zheng YT#, Zhao B, Shao TF, Shi QL, Zhou N, Cai WM. Encapsulation of liver microsomes into a thermosensitive hydrogel for characterization of drug metabolism and toxicity. Biomaterials. 2013; 34(38): 9770-8.

9. Wang J, Yu Y, Shen H, Qing T, Zheng Y, Li Q, Mo X, Wang S, Li N, Chai R, Xu B, Liu M, Brindley PJ, McManus DP, Feng Z, Shi L, Hu W. Dynamic transcriptomes identify biogenic amines and insect-like hormonal regulation for mediating reproduction in Schistosoma japonicum. Nature Communications. 2017; 8: 14693.22.

10. Su Z#, Łabaj PP#, Li S#, Thierry-Mieg J#, Thierry-Mieg D#, Shi W#, Wang C, Schroth GP, Setterquist RA, Thompson JF, Jones WD, Xiao W, Xu W, ,…, Zheng YT, …, Kreil DP*, Mason CE*, Shi L*. A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium. Nature Biotechnology, 32(9):903-14 (2014).