hao_w@fudan.edu.cn

摘要

研究方向:  肠道内生态紊乱与肠道菌失衡；肠道菌与糖尿病、心血管疾病等代谢性疾病之间的因果关系研究；肠道菌对药物及饮食干预的影响；多组学数据整合；细菌基因组突变与进化研究。

2002-2005，山东理工大学生命科学学院，获工学学士学位；

2007-2012，浙江大学沃森基因研究院，获理学博士学位；

2012-2014，中国科学院北京基因组研究所，助理研究员；

2015-2020，瑞典哥德堡大学Sahlgrenska医院，博士后；

2021-至今，复旦大学人类表型组研究院，青年研究员。

1）肠道内生态紊乱与肠道菌失衡；

2）肠道菌与糖尿病、心血管疾病等代谢性疾病之间的因果关系研究；

3）肠道菌对药物及饮食干预的影响；

4）多组学数据整合；

5）细菌基因组突变与进化研究

1. Hao Wu*, Valentina Tremaroli*, Caroline Schmidt, Annika Lundqvist, Lisa M Olsson, Manuela Krämer, Anders Gummesson, Rosie Perkins, Göran Bergström#, Fredrik Bäckhed#. The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study. 2020. Cell Metabolism 32 (3), 379-390. e3

2. Ara Koh, Antonio Molinaro, Marcus Ståhlman, Muhammad Tanweer Khan, Caroline Schmidt, Louise Mannerås-Holm, Hao Wu, Alba Carreras, Heeyoon Jeong, Louise E Olofsson, Per-Olof Bergh, Victor Gerdes, Annick Hartstra, Maurits de Brauw, Rosie Perkins, Max Nieuwdorp, Göran Bergström, Fredrik Bäckhed#. Microbially produced imidazole propionate impairs insulin signaling through mTORC1. 2018. Cell 175 (4), 947-961. e17

3. Adil Mardinoglu*, Hao Wu*, Elias Bjornson, Cheng Zhang, Antti Hakkarainen, Sari M Räsänen, Sunjae Lee, Rosellina M Mancina, Mattias Bergentall, Kirsi H Pietiläinen, Sanni Söderlund, Niina Matikainen, Marcus Ståhlman, Per-Olof Bergh, Martin Adiels, Brian D Piening, Marit Granér, Nina Lundbom, Kevin J Williams, Stefano Romeo, Jens Nielsen, Michael Snyder, Mathias Uhlén, Göran Bergström, Rosie Perkins, Hanns-Ulrich Marschall, Fredrik Bäckhed#, Marja-Riitta Taskinen, Jan Borén#. An integrated understanding of the rapid metabolic benefits of a carbohydrate-restricted diet on hepatic steatosis in humans. 2018. Cell metabolism 27 (3), 559-571. e5

4. Hao Wu*, Eduardo Esteve*, Valentina Tremaroli, Muhammad Tanweer Khan, Robert Caesar, Louise Mannerås-Holm, Marcus Ståhlman, Lisa M Olsson, Matteo Serino, Mercè Planas-Fèlix, Gemma Xifra, Josep M Mercader, David Torrents, Rémy Burcelin, Wifredo Ricart, Rosie Perkins, José Manuel Fernàndez-Real#, Fredrik Bäckhed#. Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. 2017. Nature medicine 23 (7), 850

5. Hao Wu*, Valentina Tremaroli*, Fredrik Bäckhed#. Linking microbiota to human diseases: a systems biology perspective. 2015. Trends in Endocrinology & Metabolism 26 (12), 758-770

6. Hao Wu, Yongjun Fang, Jun Yu#, Zhang Zhang#. The quest for a unified view of bacterial land colonization. 2014. The ISME journal 8 (7), 1358-1369