Information
Work Experience
Research Interests
Awards
Selected Publications
Lei Wang
| 职称 | Professor |
| 电话 | |
| 地址 | Medical Genetics in Fudan University |
| 摘要 | Wang’s research focused on reproductive genetics. He is investigating on genetic basis and molecular mechanism of diseases responsible for female infertility caused by abnormal development of oocytes and early embryos. He was the first to show oocyte maturation arrest is a new Mendelian disease (MIM:616780) and he identified the first and second disease-causing genes (TUBB8 and PATL2) for the disease. Besides, he also identified a few novel genes responsible for other kinds of female infertility, including fertilization failure, early embryonic arrest, et al. His work incorporate disease pedigree, population cohort, cell model and mouse model to identify pathogenic genes responsible for diseases related to female infertility and its molecular mechanism. The findings were published in several journals, such as N Engl J Med, Am J Hum Genet, J Med Genet, et al. The findings will provide molecular biomarkers for quality evaluation of oocytes and embryos, help patients having precision genetic diagnosis and pave the way for the future treatment. |
| 研究方向 | Wang’s research focused on reproductive genetics. He is investigating on genetic basis and molecular mechanism of diseases responsible for female infertility caused by abnormal development of oocytes and early embryos. He was the first to show oocyte maturation arrest is a new Mendelian disease (MIM:616780) and he identified the first and second disease-causing genes (TUBB8 and PATL2) for the disease. Besides, he also identified a few novel genes responsible for other kinds of female infertility, including fertilization failure, early embryonic arrest, et al. His work incorporate disease pedigree, population cohort, cell model and mouse model to identify pathogenic genes responsible for diseases related to female infertility and its molecular mechanism. The findings were published in several journals, such as N Engl J Med, Am J Hum Genet, J Med Genet, et al. The findings will provide molecular biomarkers for quality evaluation of oocytes and embryos, help patients having precision genetic diagnosis and pave the way for the future treatment. |
| 代表论文 | 1. Qing Sang*#, Bin Li*, Yanping Kuang*, Xueqian Wang*, Zhihua Zhang*, Biaobang Chen*, Zheng Yan, Qifeng Lv, Ling Wu, Xiaoyan Mao, Yao Xu, Jian Mu, Qiaoli Li, Li Jin, Lin He, Lei Wang#. Homozygous mutations in WEE2 cause fertilization failure and female infertility. Am J Hum Genet, 2018, Apr 5;102(4):649-657 (#Corresponding author) 2. Biaobang Chen, Zhihua Zhang, Xiaoxi Sun, Yanping Kuang, Xiaoyan Mao, Xueqian Wang, Zheng Yan, Bin Li, Yao Xu, Min Yu, Jing Fu, Jian Mu, Zhou Zhou, Qiaoli Li, Li Jin, Lin He, Qing Sang# and Lei Wang#. Biallelic mutations in PATL2 cause female infertility characterized by oocyte maturation arrest. Am J Hum Genet, 2017 Oct 5;101(4):609-615 (#Corresponding author) 3. Ruizhi Feng*, Qing Sang*, Yanping Kuang*, Xiaoxi Sun*，Zheng Yan*, Shaozhen Zhang*, Juanzi Shi, Guoling Tian, Anna Luchniak, Yusuke Fukuda, Bin Li, Min Yu, Junling Chen,Yao Xu, Luo Guo, Ronggui Qu, Xueqian Wang, Zhaogui Sun, Miao Liu, Huijuan Shi, Hongyan Wang, Yi Feng, Ruijin Shao, Renjie Chai, Qiaoli Li, Qinghe Xing, Rui Zhang, Eva Nogales, Li Jin, Lin He, Mohan L. Gupta, Jr., Nicholas J. Cowan# and Lei Wang#. Mutations in TUBB8 and Human oocyte meiotic arrest. N Engl J Med. 2016; 374:223-32. (#Corresponding author) (NEJM publish an Editorial for this paper in the same issue) 4. Yao Xu*, Yingli Shi*, Min Yu*, Jing Fu*, Ruizhi Feng, Qing Sang, Bo Liang, Biaobang Chen, Ronggui Qu, Bin Li, Zheng Yan, Xiaoyan Mao, Yanping Kuang, Li Jin, Lin He, Xiaoxi Sun# and Lei Wang#. Mutations in PADI6 causes female infertility characterized by early embryonic arrest. Am J Hum Genet. 2016, Sep 1;99(3):744-52. (#Corresponding author) 5. Ruizhi Feng, Zheng Yan, Bin Li, Min Yu, Qing Sang, Guoling Tian，Yao Xu , Biaobang Chen, Ronggui Qu, Zhaogui Sun, Xiaoxi Sun, Li Jin, Lin He, Yanping Kuang, Nicholas J. Cowan and Lei Wang*. Mutations in TUBB8 cause a multiplicity of phenotype in human oocytes and early embryos. J Med Genet 2016, Oct;53(10):662-71. (*Corresponding author) (Cover Story) |
| 邮箱 | wangleiwanglei@fudan.edu.cn |
获奖情况 | 1. 2017 The first prize in National Women’s health Award |